Muscle and stem cells: Repair after major trauma

Muscle and stem cells: Repair after major trauma


Major injury can cause
extensive trauma to the muscle including toxins such as a snake bite. Even after extensive damage small groups of healthy cells
can be found. These cells,
including muscle stem cells, engage in the regeneration process. Satellite cells activate and generate
daughter myoblasts that begin the process of rebuilding
the destroyed muscle fibres. Residual debris is removed
by the macrophages. New muscle fibres are generated
by the differentiation and fusion of hundreds of myoblasts within the collagen matrix of
the basement membranes. During this regeneration process,
satellite cells will self-renew. They are then set aside
for future repair events.